- Review Article
- Genetics and Metabolism
- Understanding the genetics of systemic lupus erythematosus using Bayesian statistics and gene network analysis
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Seoung Wan Nam, Kwang Seob Lee, Jae Won Yang, Younhee Ko, Michael Eisenhut, Keum Hwa Lee, Jae Il Shin, Andreas Kronbichler
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Clin Exp Pediatr. 2021;64(5):208-222. Published online July 15, 2020
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Bayesian false-discovery probability and false-positive report probability are the 2 major Bayesian methods used to evaluate noteworthiness of a genetic variant.
Application of stricter P value is needed to confirm statistical significance in meta-analyses.
Gene network analysis of noteworthy genetic variants shows a blueprint of the genetic background in complex diseases. |
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- Nephrology (Genitourinary)
- Treatment of refractory IgA vasculitis with dapsone: a systematic review
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Keum Hwa Lee, Sung Hwi Hong, Jinhae Jun, Youngheun Jo, Woogyeong Jo, Dayeon Choi, Jeongho Joo, Guhyun Jung, Sunghee Ahn, Andreas Kronbichler, Michael Eisenhut, Jae Il Shin
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Clin Exp Pediatr. 2020;63(5):158-163. Published online September 24, 2019
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IgA vasculitis, formerly known as Henoch-Schönlein purpura, is a systemic IgA-mediated vasculitis of the small vessels commonly seen in children. The natural history of IgA vasculitis is generally self-limiting; however, one-third of patients experience symptom recurrence and a refractory course. This systematic review examined the use of dapsone in refractory IgA vasculitis cases. A literature search of PubMed databases retrieved... |
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- Case Report
- Nephrology (Genitourinary)
- Successful treatment of tubulointerstitial nephritis and uveitis with steroid and azathioprine in a 12-year-old boy
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Ji Eun Kim, Se Jin Park, Ji Young Oh, Hyeon Joo Jeong, Ji Hong Kim, Jae Il Shin
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Clin Exp Pediatr. 2016;59(Suppl 1):S99-S102. Published online November 30, 2016
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Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease, often underdiagnosed or misdiagnosed in children. We describe the case of a 12-year-old boy who presented to Severance Hospital with a 1-month history of bilateral conjunctival injection. He was first evaluated by an Ophthalmologist in another hospital and diagnosed with panuveitis. Laboratory tests indicated renal failure, and a renal biopsy... |
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- Review Article
- Nephrology (Genitourinary)
- Pathogenesis of minimal change nephrotic syndrome: an immunological concept
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Seong Heon Kim, Se Jin Park, Kyoung Hee Han, Andreas Kronbichler, Moin A. Saleem, Jun Oh, Beom Jin Lim, Jae Il Shin
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Clin Exp Pediatr. 2016;59(5):205-211. Published online May 31, 2016
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Idiopathic nephrotic syndrome (INS) in children is characterized by massive proteinuria and hypoalbuminemia. Minimal change nephrotic syndrome (MCNS) is the most common form of INS in children. The pathogenesis of MCNS still remains unclear, however, several hypotheses have been recently proposed. For several decades, MCNS has been considered a T-cell disorder, which causes the impairment of the glomerular filtration barrier... |
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- Original Article
- Nephrology (Genitourinary)
- Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection
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Song Yi Han, I Re Lee, Se Jin Park, Ji Hong Kim, Jae Il Shin
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Clin Exp Pediatr. 2016;59(3):139-144. Published online March 31, 2016
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Purpose Acute pyelonephritis (APN) is a serious bacterial infection that can cause renal scarring in children. Early identification of APN is critical to improve treatment outcomes. The neutrophil-lymphocyte ratio (NLR) is a prognostic marker of many diseases, but it has not yet been established in urinary tract infection (UTI). The aim of this study was to determine whether NLR is a... |
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- Review Article
- Inflammation and hyponatremia: an underrecognized condition?
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Se Jin Park, Jae Il Shin
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Clin Exp Pediatr. 2013;56(12):519-522. Published online December 20, 2013
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Timely diagnosis of hyponatremia is important for preventing potential morbidity and mortality as it is often an indicator of underlying disease. The most common cause of eurvolemic hyponatremia is the syndrome of inappropriate antidiuretic hormone (SIADH) secretion. Recent studies have demonstrated that proinflammatory cytokines such as interleukin (IL) 1β and IL-6 are involved in the development of hyponatremia, a condition... |
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- Case Report
- Urinary bladder rupture during voiding cystourethrography
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Kyong Ok Lee, Se Jin Park, Jae Il Shin, Suk Young Lee, Kee Hyuck Kim
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Clin Exp Pediatr. 2012;55(5):181-184. Published online May 21, 2012
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Voiding cystourethrography (VCUG) is a commonly performed diagnostic procedure for the evaluation of vesicoureteral reflux with urinary tract infection or congenital renal diseases in children. The procedure is relatively simple and cost-effective, and complications are very rare. The iatrogenic complication of VCUG range from discomfort, urinary tract infection to bacteremia, as well as bladder rupture. Bladder rupture is a rare... |
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- Review Article
- Complications of nephrotic syndrome
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Se Jin Park, Jae Il Shin
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Clin Exp Pediatr. 2011;54(8):322-328. Published online August 31, 2011
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Nephrotic syndrome (NS) is one of the most common glomerular diseases that affect children. Renal histology reveals the presence of minimal change nephrotic syndrome (MCNS) in more than 80% of these patients. Most patients with MCNS have favorable outcomes without complications. However, a few of these children have lesions of focal segmental glomerulosclerosis, suffer from severe and prolonged proteinuria, and... |
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